In the modern-day global, a number of therapeutic proteins which includes vaccines, antigens and hormones are being advanced using one-of-a-kind sophisticated biotechnological strategies like Recombinant DNA technology and protein purification. However, the predominant glitches inside the foremost utilization of therapeutic proteins and peptides by way of the oral path are their large hepatic first-pass metabolism, degradation inside the gastrointestinal tract due to enzymes and pH-dependent factors, large molecular size and poor permeation. These problems can be overcome by adopting strategies consisting of chemical transformation of protein structures, enzyme inhibitors, mucoadhesive polymers and permeation enhancers. Being invasive, parenteral route is inconvenient for the administration of protein and peptides, numerous research endeavours have been undertaken to formulate a better delivery system for proteins and peptides with major emphasis on non-invasive routes along with oral, transdermal, vaginal, rectal, pulmonary and intrauterine. This overview article emphasizes on the latest improvements made inside the delivery of protein and peptides through a non-invasive (peroral) route into the body.
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